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Southampton make five changes after the 2-0 Championship win over Oxford United. Nathan Wood, Cam Bragg, Caspar Jander, Léo Scienza and Ross Stewart come in for Cameron Archer, Shea Charles and Cyle Larin, who are benched, and Flynn Downes and captain Jack Stephens, who miss out altogether.
Arsenal make seven changes following the Carabao Cup final, the most eye-catching of which is a start for 16-year-old Max Dowman. Cristhian Mosquera, Myles Lewis-Skelly, Christian Nørgaard, Gabriel Martinelli, Gabriel Jesus and captain Martin Ødegaard also step up; William Saliba, Viktor Gyökeres and Martín Zubimendi are on the bench, while Declan Rice, Bukayo Saka, Piero Hincapié and Leandro Trossard are all absent.
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